TRT
TRT Program · personalized dosing
Clinical Overview
TRT Program
Rx
A personalized testosterone replacement program. Based on your labs, age, and state, you may be prescribed injectable testosterone, a topical cream, or oral therapy, with anti-estrogen support included if your labs call for it.
$109
/ mo
The data on testosterone
Testosterone decline is well documented
Testosterone falls with age, and population-wide levels have also trended lower across generations. Here’s what the published research shows.
What the evidence actually shows
TRT (testosterone replacement therapy) is a well-established treatment for clinically low testosterone. Your clinician reviews your labs, age, and health history, then prescribes the formulation and dose that fits your biology, with anti-estrogen support added only if your labs call for it.
HUMAN EVIDENCE
Thousands of patients across multiple randomized controlled trials, including the large-scale TRAVERSE cardiovascular safety trial (over 5,000 men).
CONTROLLED EFFICACY
Multiple randomized controlled trials support testosterone's effect on confirmed hypogonadism symptoms, body composition, and bone density.
LONG-TERM SAFETY
Generally well tolerated under clinician monitoring; known risks include erythrocytosis, prostate-specific concerns, and fertility suppression, which is why ongoing labs are part of every program.
Regulatory status
Testosterone is an FDA-approved, Schedule III controlled substance when prescribed for confirmed hypogonadism. Enclomiphene and anastrozole used alongside testosterone therapy are prescribed off-label based on your clinician's judgment. All medications are dispensed by a licensed, US-based pharmacy.
HUMAN AND PRECLINICAL EVIDENCE
What the research shows
Each finding below is shown with its original context, so the type and strength of evidence is clear.
Clinical trials · TRAVERSE cardiovascular safety
A large randomized trial followed over 5,000 men on testosterone therapy and found no increased risk of major cardiovascular events compared to placebo, addressing a long-standing safety question.
Clinical evidence · Symptom and body composition improvement
Randomized trials consistently show testosterone therapy improves sexual function, mood, and lean muscle mass in men with confirmed low testosterone, with effects typically emerging within 3 to 6 months.
Clinical evidence · Enclomiphene and fertility preservation
Unlike exogenous testosterone, enclomiphene raises the body's own testosterone production without suppressing sperm production, making it an option for patients who want to preserve fertility.
WHAT THIS MEANS
The evidence supports testosterone replacement therapy as a safe, effective option for confirmed low testosterone when properly monitored. Your specific formulation — whether injectable, topical, or oral — and whether anti-estrogen support is included, is determined by your individual labs and health history, not a standalone choice.
What is TRT Program?
A personalized testosterone replacement program. Based on your labs, age, and state, you may be prescribed injectable testosterone, a topical cream, or oral therapy, with anti-estrogen support included if your labs call for it.
The TRT Program is built around one outcome: restoring testosterone to a healthy range safely. After reviewing your intake, labs, and health history, a licensed clinician determines whether injectable testosterone cypionate, a topical cream, or oral enclomiphene is the right fit for your biology, age, and goals. If your labs show elevated estrogen conversion, anastrozole is added to your program at no extra cost.
MECHANISM OF ACTION
Testosterone cypionate and topical testosterone directly replace deficient testosterone. Enclomiphene works differently: it blocks estrogen's negative feedback on the pituitary, stimulating the body's own LH and FSH to raise natural testosterone production without suppressing fertility. Anastrozole, when needed, blocks the aromatase enzyme that converts testosterone into estradiol.
Mechanism and clinical outcomes are evaluated separately — see the research evidence above for what has been directly observed in patients.
Safety limits and suitability
These guardrails apply regardless of how established the evidence is, and are reviewed with your clinician before starting treatment.
What is not known
The right formulation, starting dose, and whether anti-estrogen support is needed varies by individual and is determined after your labs and intake are reviewed, not chosen upfront.
Who should not use it
Known or suspected prostate cancer, active breast cancer, desire for current fertility without a fertility-preserving plan, uncontrolled heart failure, untreated severe obstructive sleep apnea, significantly elevated hematocrit, or unexplained elevated PSA without prior urologic evaluation.
Monitoring and expectations
Your clinician orders baseline labs (total and free testosterone, hematocrit, PSA when age-appropriate, and estradiol) before starting, then rechecks periodically to confirm your levels are in a healthy range and adjust your formulation, dose, or anti-estrogen support as needed.
MEDICAL REVIEW
Dr. Reza Omid
MD, MPH
Content reviewed against primary medical and regulatory sources
Review date
Selected medical and regulatory references
Primary and regulatory sources supporting the clinical and regulatory information on this page.
Frequently asked questions
Start with a clinical evaluation
Diagnosis and suitability come before a product decision. Completing the intake does not guarantee that a clinician will prescribe treatment.